diff --git a/cmd/erasure-multipart.go b/cmd/erasure-multipart.go
index 2e3d49aa8..17301851b 100644
--- a/cmd/erasure-multipart.go
+++ b/cmd/erasure-multipart.go
@@ -19,6 +19,7 @@ package cmd
 
 import (
 	"context"
+	"encoding/base64"
 	"errors"
 	"fmt"
 	"io"
@@ -41,7 +42,15 @@ import (
 )
 
 func (er erasureObjects) getUploadIDDir(bucket, object, uploadID string) string {
-	return pathJoin(er.getMultipartSHADir(bucket, object), uploadID)
+	uploadUUID := uploadID
+	uploadBytes, err := base64.StdEncoding.DecodeString(uploadID)
+	if err == nil {
+		slc := strings.SplitN(string(uploadBytes), ".", 2)
+		if len(slc) == 2 {
+			uploadUUID = slc[1]
+		}
+	}
+	return pathJoin(er.getMultipartSHADir(bucket, object), uploadUUID)
 }
 
 func (er erasureObjects) getMultipartSHADir(bucket, object string) string {
@@ -436,9 +445,9 @@ func (er erasureObjects) newMultipartUpload(ctx context.Context, bucket string,
 		partsMetadata[index].ModTime = modTime
 		partsMetadata[index].Metadata = userDefined
 	}
-
-	uploadID := mustGetUUID()
-	uploadIDPath := er.getUploadIDDir(bucket, object, uploadID)
+	uploadUUID := mustGetUUID()
+	uploadID := base64.StdEncoding.EncodeToString([]byte(fmt.Sprintf("%s.%s", globalDeploymentID, uploadUUID)))
+	uploadIDPath := er.getUploadIDDir(bucket, object, uploadUUID)
 
 	// Write updated `xl.meta` to all disks.
 	if _, err := writeUniqueFileInfo(ctx, onlineDisks, minioMetaMultipartBucket, uploadIDPath, partsMetadata, writeQuorum); err != nil {
diff --git a/cmd/erasure-single-drive.go b/cmd/erasure-single-drive.go
index c597749d3..0bd4a0323 100644
--- a/cmd/erasure-single-drive.go
+++ b/cmd/erasure-single-drive.go
@@ -20,6 +20,7 @@ package cmd
 import (
 	"bytes"
 	"context"
+	"encoding/base64"
 	"errors"
 	"fmt"
 	"io"
@@ -1943,7 +1944,15 @@ func (es *erasureSingle) restoreTransitionedObject(ctx context.Context, bucket s
 }
 
 func (es *erasureSingle) getUploadIDDir(bucket, object, uploadID string) string {
-	return pathJoin(es.getMultipartSHADir(bucket, object), uploadID)
+	uploadUUID := uploadID
+	uploadBytes, err := base64.StdEncoding.DecodeString(uploadID)
+	if err == nil {
+		slc := strings.SplitN(string(uploadBytes), ".", 2)
+		if len(slc) == 2 {
+			uploadUUID = slc[1]
+		}
+	}
+	return pathJoin(es.getMultipartSHADir(bucket, object), uploadUUID)
 }
 
 func (es *erasureSingle) getMultipartSHADir(bucket, object string) string {
@@ -2190,9 +2199,9 @@ func (es *erasureSingle) newMultipartUpload(ctx context.Context, bucket string,
 		partsMetadata[index].ModTime = modTime
 		partsMetadata[index].Metadata = opts.UserDefined
 	}
-
-	uploadID := mustGetUUID()
-	uploadIDPath := es.getUploadIDDir(bucket, object, uploadID)
+	uploadUUID := mustGetUUID()
+	uploadID := base64.StdEncoding.EncodeToString([]byte(fmt.Sprintf("%s.%s", globalDeploymentID, uploadUUID)))
+	uploadIDPath := es.getUploadIDDir(bucket, object, uploadUUID)
 
 	// Write updated `xl.meta` to all disks.
 	if _, err := writeUniqueFileInfo(ctx, onlineDisks, minioMetaMultipartBucket, uploadIDPath, partsMetadata, writeQuorum); err != nil {
diff --git a/cmd/erasure-utils.go b/cmd/erasure-utils.go
index 820a5df2f..434267b2b 100644
--- a/cmd/erasure-utils.go
+++ b/cmd/erasure-utils.go
@@ -20,8 +20,10 @@ package cmd
 import (
 	"bytes"
 	"context"
+	"encoding/base64"
 	"fmt"
 	"io"
+	"strings"
 
 	"github.com/klauspost/reedsolomon"
 	xioutil "github.com/minio/minio/internal/ioutil"
@@ -117,3 +119,16 @@ func writeDataBlocks(ctx context.Context, dst io.Writer, enBlocks [][]byte, data
 	// Success.
 	return totalWritten, nil
 }
+
+// returns deploymentID from uploadID
+func getDeplIDFromUpload(uploadID string) (string, error) {
+	uploadBytes, err := base64.StdEncoding.DecodeString(uploadID)
+	if err != nil {
+		return "", fmt.Errorf("error parsing uploadID %s (%w)", uploadID, err)
+	}
+	slc := strings.SplitN(string(uploadBytes), ".", 2)
+	if len(slc) != 2 {
+		return "", fmt.Errorf("uploadID %s has incorrect format", uploadID)
+	}
+	return slc[0], nil
+}
diff --git a/cmd/generic-handlers.go b/cmd/generic-handlers.go
index 05f83519a..69f0ecb32 100644
--- a/cmd/generic-handlers.go
+++ b/cmd/generic-handlers.go
@@ -576,3 +576,47 @@ func setCriticalErrorHandler(h http.Handler) http.Handler {
 		h.ServeHTTP(w, r)
 	})
 }
+
+// setUploadForwardingHandler middleware forwards multiparts requests
+// in a site replication setup to peer that initiated the upload
+func setUploadForwardingHandler(h http.Handler) http.Handler {
+	return http.HandlerFunc(func(w http.ResponseWriter, r *http.Request) {
+		if !globalSiteReplicationSys.isEnabled() ||
+			guessIsHealthCheckReq(r) || guessIsMetricsReq(r) ||
+			guessIsRPCReq(r) || guessIsLoginSTSReq(r) || isAdminReq(r) {
+			h.ServeHTTP(w, r)
+			return
+		}
+		bucket, object := request2BucketObjectName(r)
+		uploadID := r.Form.Get(xhttp.UploadID)
+
+		if bucket != "" && object != "" && uploadID != "" {
+			deplID, err := getDeplIDFromUpload(uploadID)
+			if err != nil {
+				writeErrorResponse(r.Context(), w, errorCodes.ToAPIErr(ErrNoSuchUpload), r.URL)
+				return
+			}
+			remote, self := globalSiteReplicationSys.getPeerForUpload(deplID)
+			if self {
+				h.ServeHTTP(w, r)
+				return
+			}
+			// forward request to peer handling this upload
+			if globalBucketTargetSys.isOffline(remote.EndpointURL) {
+				writeErrorResponse(r.Context(), w, errorCodes.ToAPIErr(ErrReplicationRemoteConnectionError), r.URL)
+				return
+			}
+
+			r.URL.Scheme = remote.EndpointURL.Scheme
+			r.URL.Host = remote.EndpointURL.Host
+			// Make sure we remove any existing headers before
+			// proxying the request to another node.
+			for k := range w.Header() {
+				w.Header().Del(k)
+			}
+			globalForwarder.ServeHTTP(w, r)
+			return
+		}
+		h.ServeHTTP(w, r)
+	})
+}
diff --git a/cmd/object-api-input-checks.go b/cmd/object-api-input-checks.go
index 8dfc6212d..9cffdedb1 100644
--- a/cmd/object-api-input-checks.go
+++ b/cmd/object-api-input-checks.go
@@ -19,10 +19,10 @@ package cmd
 
 import (
 	"context"
+	"encoding/base64"
 	"runtime"
 	"strings"
 
-	"github.com/google/uuid"
 	"github.com/minio/minio-go/v7/pkg/s3utils"
 	"github.com/minio/minio/internal/logger"
 )
@@ -112,7 +112,8 @@ func checkListMultipartArgs(ctx context.Context, bucket, prefix, keyMarker, uplo
 				KeyMarker:      keyMarker,
 			}
 		}
-		if _, err := uuid.Parse(uploadIDMarker); err != nil {
+		_, err := base64.StdEncoding.DecodeString(uploadIDMarker)
+		if err != nil {
 			logger.LogIf(ctx, err)
 			return MalformedUploadID{
 				UploadID: uploadIDMarker,
diff --git a/cmd/routers.go b/cmd/routers.go
index d04dac112..3d59afc43 100644
--- a/cmd/routers.go
+++ b/cmd/routers.go
@@ -61,6 +61,8 @@ var globalHandlers = []mux.MiddlewareFunc{
 	setRequestValidityHandler,
 	// set x-amz-request-id header.
 	addCustomHeaders,
+	// Add upload forwarding handler for site replication
+	setUploadForwardingHandler,
 	// Add bucket forwarding handler
 	setBucketForwardingHandler,
 	// Add new handlers here.
diff --git a/cmd/site-replication.go b/cmd/site-replication.go
index b52e7ae50..3125af66d 100644
--- a/cmd/site-replication.go
+++ b/cmd/site-replication.go
@@ -4843,3 +4843,27 @@ func isUserInfoEqual(u1, u2 madmin.UserInfo) bool {
 func isPolicyMappingEqual(p1, p2 srPolicyMapping) bool {
 	return p1.Policy == p2.Policy && p1.IsGroup == p2.IsGroup && p1.UserOrGroup == p2.UserOrGroup
 }
+
+type srPeerInfo struct {
+	madmin.PeerInfo
+	EndpointURL *url.URL
+}
+
+// getPeerForUpload returns the site replication peer handling this upload. Defaults to local cluster otherwise
+func (c *SiteReplicationSys) getPeerForUpload(deplID string) (pi srPeerInfo, local bool) {
+	ci, _ := c.GetClusterInfo(GlobalContext)
+	if !ci.Enabled {
+		return pi, true
+	}
+	for _, site := range ci.Sites {
+		if deplID == site.DeploymentID {
+			ep, _ := url.Parse(site.Endpoint)
+			pi = srPeerInfo{
+				PeerInfo:    site,
+				EndpointURL: ep,
+			}
+			return pi, site.DeploymentID == globalDeploymentID
+		}
+	}
+	return pi, true
+}